Compound Detail
CHEMBL349371
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Basic Information
| ChEMBL ID | CHEMBL349371 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HWFCHCRFQWEFMU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
261.1
MW (Da)
2.16
ALogP
3
HBA
1
HBD
55.8
PSA (Ų)
0.91
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 6.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck CHEMBL258 | Kd | 6.62 | 6.62 | 240.0 | 1 |
| Tyrosine-protein kinase Fyn CHEMBL1841 | Kd | 6.3 | 6.3 | 500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck | Kd | = | 240.0 | nM | 6.62 | Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase | 10072676 |
| Tyrosine-protein kinase Fyn | Kd | = | 500.0 | nM | 6.3 | Dissociation constant for binding to SH2 domain of Fyn protein kinase | 10072676 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10072676 | 10.1021/jm980663f | Tyrosine-protein kinase Lck | 1 |
| 10072676 | 10.1021/jm980663f | Tyrosine-protein kinase Fyn | 1 |
Data from ChEMBL 36 via Core Engine