Assay Detail
Binding
CHEMBL682779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant for binding to SH2 domain of Fyn protein kinase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.53 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165399 | — | — | 1 | 7.22 |
| CHEMBL12253 | — | — | 1 | 6.82 |
| CHEMBL8682 | — | — | 1 | 6.62 |
| CHEMBL349371 | — | — | 1 | 6.30 |
| CHEMBL164585 | — | — | 1 | 6.16 |
| CHEMBL539 | ACETIC ACID | 4.0 | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165399 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL12253 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL8682 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL349371 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL164585 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL539 | ACETIC ACID | Kd | = | 900.0 | nM | 6.05 |