Assay Detail
Functional
CHEMBL823523
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Compound was tested for its ability to inhibit calcium influx in human U937 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.62 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331884 | — | — | 1 | 9.70 |
| CHEMBL332680 | — | — | 1 | 9.52 |
| CHEMBL119214 | — | — | 1 | 9.30 |
| CHEMBL21333 | PRANLUKAST | 4.0 | 1 | 9.00 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 9.00 |
| CHEMBL331747 | — | — | 1 | 8.70 |
| CHEMBL300701 | — | — | 1 | 8.10 |
| CHEMBL120200 | — | — | 1 | 7.77 |
| CHEMBL442150 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331884 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL332680 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL119214 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL21333 | PRANLUKAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL331747 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL300701 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL120200 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL442150 | — | IC50 | = | 310.0 | nM | 6.51 |