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Assay Detail

CHEMBL823567

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Binding
Inhibition of bovine cAMP-dependent protein kinase A.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.
Davis PD, Hill CH, Lawton G, Nixon JS, Wilkinson SE, Hurst SA, Keech E, Turner SE.
J Med Chem (1992) 35 : 177 -184
PubMed 1732526 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.74 5.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51758 1 5.08
CHEMBL51708 1 4.94
CHEMBL266487 RO-316233 1 4.93
CHEMBL53906 1 4.89
CHEMBL54794 1 4.85
CHEMBL52128 1 4.84
CHEMBL301515 1 4.79
CHEMBL52853 1 4.67
CHEMBL299519 1 4.67
CHEMBL55151 1 4.64
CHEMBL53695 1 4.51
CHEMBL50629 1 4.09
CHEMBL54533 1 -
CHEMBL301349 1 -
CHEMBL54613 1 -
CHEMBL301337 1 -
CHEMBL54425 1 -
CHEMBL54209 1 -
CHEMBL301389 1 -
CHEMBL300397 1 -
CHEMBL54547 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51758 IC50 = 8400.0 nM 5.08
CHEMBL51708 IC50 = 11500.0 nM 4.94
CHEMBL266487 RO-316233 IC50 = 11800.0 nM 4.93
CHEMBL53906 IC50 = 13000.0 nM 4.89
CHEMBL54794 IC50 = 14000.0 nM 4.85
CHEMBL52128 IC50 = 14500.0 nM 4.84
CHEMBL301515 IC50 = 16100.0 nM 4.79
CHEMBL52853 IC50 = 21500.0 nM 4.67
CHEMBL299519 IC50 = 21300.0 nM 4.67
CHEMBL55151 IC50 = 23000.0 nM 4.64
CHEMBL53695 IC50 = 31000.0 nM 4.51
CHEMBL50629 IC50 = 82000.0 nM 4.09
CHEMBL54533 IC50 > 100000.0 nM -
CHEMBL301349 IC50 > 100000.0 nM -
CHEMBL54613 IC50 > 100000.0 nM -
CHEMBL301337 IC50 > 100000.0 nM -
CHEMBL54425 IC50 > 100000.0 nM -
CHEMBL54209 IC50 > 100000.0 nM -
CHEMBL301389 IC50 > 100000.0 nM -
CHEMBL300397 IC50 > 100000.0 nM -
CHEMBL54547 IC50 > 100000.0 nM -