Assay Detail
Functional
CHEMBL823612
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of [35S]GTP-gamma-S, binding to rat brain membranes by adenosine A1 receptor activation
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.01 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 7.88 |
| CHEMBL284969 | — | — | 1 | 7.52 |
| CHEMBL2113518 | — | — | 1 | 7.24 |
| CHEMBL2113430 | — | — | 1 | 7.06 |
| CHEMBL2113390 | — | — | 1 | 6.39 |
| CHEMBL608306 | — | — | 1 | 6.37 |
| CHEMBL2113389 | — | — | 1 | 6.32 |
| CHEMBL2113521 | — | — | 1 | 6.15 |
| CHEMBL2113423 | — | — | 1 | 6.15 |
| CHEMBL2113478 | — | — | 1 | 5.82 |
| CHEMBL1790734 | — | — | 1 | 5.81 |
| CHEMBL1790737 | — | — | 1 | 5.43 |
| CHEMBL1790735 | — | — | 1 | 5.29 |
| CHEMBL1790733 | — | — | 1 | 5.24 |
| CHEMBL1790739 | — | — | 1 | 5.21 |
| CHEMBL611851 | — | — | 1 | 5.20 |
| CHEMBL312981 | — | — | 1 | 5.18 |
| CHEMBL1790730 | — | — | 1 | 5.02 |
| CHEMBL1790715 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | EC50 | = | 13.3 | nM | 7.88 |
| CHEMBL284969 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2113518 | — | EC50 | = | 57.3 | nM | 7.24 |
| CHEMBL2113430 | — | EC50 | = | 86.4 | nM | 7.06 |
| CHEMBL2113390 | — | EC50 | = | 408.0 | nM | 6.39 |
| CHEMBL608306 | — | EC50 | = | 431.0 | nM | 6.37 |
| CHEMBL2113389 | — | EC50 | = | 475.0 | nM | 6.32 |
| CHEMBL2113521 | — | EC50 | = | 704.0 | nM | 6.15 |
| CHEMBL2113423 | — | EC50 | = | 709.0 | nM | 6.15 |
| CHEMBL2113478 | — | EC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL1790734 | — | EC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL1790737 | — | EC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL1790735 | — | EC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL1790733 | — | EC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL1790739 | — | EC50 | = | 6180.0 | nM | 5.21 |
| CHEMBL611851 | — | EC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL312981 | — | EC50 | = | 6580.0 | nM | 5.18 |
| CHEMBL1790730 | — | EC50 | = | 9640.0 | nM | 5.02 |
| CHEMBL1790715 | — | EC50 | = | 13700.0 | nM | 4.86 |