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Assay Detail

CHEMBL823860

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of carboxylesterase in murine liver microsomes.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Liver
Subcellular Microsome
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Acylcarnitine hydrolase (CHEMBL2217)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors.
Wheelock CE, Colvin ME, Uemura I, Olmstead MM, Sanborn JR, Nakagawa Y, Jones AD, Hammock BD.
J Med Chem (2002) 45 : 5576 -5593
PubMed 12459025 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.58 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL155514 1 9.30
CHEMBL440542 1 7.90
CHEMBL155513 1 7.88
CHEMBL153080 1 7.65
CHEMBL421992 1 6.92
CHEMBL153015 1 6.79
CHEMBL155396 1 6.35
CHEMBL155621 1 6.35
CHEMBL153177 1 6.24
CHEMBL152225 1 4.80
CHEMBL152843 1 4.42
CHEMBL152698 1 4.35
CHEMBL153107 1 -
CHEMBL152577 1 -
CHEMBL150821 1 -
CHEMBL152376 1 -
CHEMBL153601 1 -
CHEMBL153556 1 -
CHEMBL356917 1 -
CHEMBL150648 1 -
CHEMBL47127 2-DECANONE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL155514 IC50 = 0.5012 nM 9.30
CHEMBL440542 IC50 = 12.59 nM 7.90
CHEMBL155513 IC50 = 13.18 nM 7.88
CHEMBL153080 IC50 = 22.39 nM 7.65
CHEMBL421992 IC50 = 120.23 nM 6.92
CHEMBL153015 IC50 = 162.18 nM 6.79
CHEMBL155396 IC50 = 446.68 nM 6.35
CHEMBL155621 IC50 = 446.68 nM 6.35
CHEMBL153177 IC50 = 575.44 nM 6.24
CHEMBL152225 IC50 = 15848.93 nM 4.80
CHEMBL152843 IC50 = 38018.94 nM 4.42
CHEMBL152698 IC50 = 44668.36 nM 4.35
CHEMBL153107 IC50 = 954992.59 nM -
CHEMBL152577 IC50 = 478630.09 nM -
CHEMBL150821 IC50 = 301995.17 nM -
CHEMBL152376 IC50 = 112201.85 nM -
CHEMBL153601 IC50 = 1778279.41 nM -
CHEMBL153556 IC50 = 426579.52 nM -
CHEMBL356917 IC50 = 2041737.94 nM -
CHEMBL150648 IC50 = 14791083.88 nM -
CHEMBL47127 2-DECANONE IC50 = 169824365.25 nM -