Assay Detail
Binding
CHEMBL823964
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.50 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.61 |
| CHEMBL305220 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | Ki | = | 24.5 | nM | 7.61 |
| CHEMBL305220 | — | Ki | = | 40.4 | nM | 7.39 |