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Assay Detail

CHEMBL824099

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Type-1 angiotensin II receptor B (CHEMBL263)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Dihydropyrimidine angiotensin II receptor antagonists.
Atwal KS, Ahmed SZ, Bird JE, Delaney CL, Dickinson KE, Ferrara FN, Hedberg A, Miller AV, Moreland S, O'Reilly BC.
J Med Chem (1992) 35 : 4751 -4763
PubMed 1469703 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 7.54 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL995 LOSARTAN POTASSIUM 4.0 1 8.05
CHEMBL191 LOSARTAN 4.0 1 7.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL995 LOSARTAN POTASSIUM Ki = 9.0 nM 8.05
CHEMBL191 LOSARTAN Ki = 95.0 nM 7.02