Assay Detail
Binding
CHEMBL824221
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Inhibition of cloned isozyme, human carbonic anhydrase IV
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 68 | 7.14 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346691 | — | — | 1 | 8.40 |
| CHEMBL2112274 | — | — | 1 | 8.40 |
| CHEMBL408856 | — | — | 1 | 8.30 |
| CHEMBL2111218 | — | — | 1 | 8.30 |
| CHEMBL34852 | — | — | 1 | 8.30 |
| CHEMBL286586 | — | — | 1 | 8.22 |
| CHEMBL34317 | — | — | 1 | 8.22 |
| CHEMBL432083 | — | — | 1 | 8.15 |
| CHEMBL285516 | — | — | 1 | 8.10 |
| CHEMBL415466 | — | — | 1 | 8.05 |
| CHEMBL154106 | — | — | 1 | 8.05 |
| CHEMBL287117 | — | — | 1 | 7.82 |
| CHEMBL416410 | — | — | 1 | 7.80 |
| CHEMBL1795062 | — | — | 1 | 7.80 |
| CHEMBL6685 | — | — | 1 | 7.77 |
| CHEMBL35338 | — | — | 1 | 7.75 |
| CHEMBL289888 | — | — | 1 | 7.72 |
| CHEMBL35118 | — | — | 1 | 7.72 |
| CHEMBL2112276 | — | — | 1 | 7.68 |
| CHEMBL287316 | — | — | 1 | 7.68 |
| CHEMBL30168 | — | — | 1 | 7.62 |
| CHEMBL286862 | — | — | 1 | 7.60 |
| CHEMBL32208 | — | — | 1 | 7.60 |
| CHEMBL34768 | — | — | 1 | 7.57 |
| CHEMBL284398 | — | — | 1 | 7.57 |
| CHEMBL32606 | — | — | 1 | 7.55 |
| CHEMBL32982 | — | — | 1 | 7.54 |
| CHEMBL32732 | — | — | 1 | 7.54 |
| CHEMBL32160 | — | — | 1 | 7.50 |
| CHEMBL32096 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346691 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2112274 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2111218 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL34852 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL408856 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL286586 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL34317 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL432083 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL285516 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL415466 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL154106 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL287117 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL416410 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1795062 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL6685 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL35338 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL289888 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL35118 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL2112276 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL287316 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL30168 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL286862 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL32208 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL34768 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL284398 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL32606 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL32732 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL32982 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL32160 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL32096 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL284617 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL286449 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL286297 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL284831 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL290348 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL6724 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL2112275 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL35385 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL13646 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL268177 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL284694 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL266240 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL408857 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL269628 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL6853 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL32836 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL35043 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 240.0 | nM | 6.62 |