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Assay Detail

CHEMBL824460

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of peroxyl radical-dependent oxidation of liposomes from soybean phosphatidylcholine by ethanol injection.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Glycine max
Subcellular Microsome
Confidence 2 — Organism
Curated By Expert

Target

Liposome (CHEMBL614676)
Type SUBCELLULAR

Publication

Synthesis and radical scavenging activity of 3,3-dialkyl-3,4-dihydro-isoquinoline 2-oxides
Bernotas RC, Thomas CE, Carr AA, Nieduzak TR, Adams G, Ohlweiler DF, Hay DA
Bioorg Med Chem Lett (1996) 6 : 1105 -1110
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.56 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL274908 1 5.52
CHEMBL12932 1 5.10
CHEMBL13204 1 4.96
CHEMBL12917 1 4.75
CHEMBL13185 1 4.68
CHEMBL13201 1 4.62
CHEMBL13368 1 4.42
CHEMBL265346 1 4.39
CHEMBL13761 1 4.35
CHEMBL13531 1 4.26
CHEMBL430100 1 4.25
CHEMBL12940 1 4.17
CHEMBL273282 1 4.17
CHEMBL274597 1 4.16
CHEMBL13172 1 -
CHEMBL13210 1 -
CHEMBL12990 1 -
CHEMBL13112 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL274908 IC50 = 3000.0 nM 5.52
CHEMBL12932 IC50 = 8000.0 nM 5.10
CHEMBL13204 IC50 = 11000.0 nM 4.96
CHEMBL12917 IC50 = 18000.0 nM 4.75
CHEMBL13185 IC50 = 21000.0 nM 4.68
CHEMBL13201 IC50 = 24000.0 nM 4.62
CHEMBL13368 IC50 = 38000.0 nM 4.42
CHEMBL265346 IC50 = 41000.0 nM 4.39
CHEMBL13761 IC50 = 45000.0 nM 4.35
CHEMBL13531 IC50 = 55000.0 nM 4.26
CHEMBL430100 IC50 = 56000.0 nM 4.25
CHEMBL12940 IC50 = 67000.0 nM 4.17
CHEMBL273282 IC50 = 67000.0 nM 4.17
CHEMBL274597 IC50 = 69000.0 nM 4.16
CHEMBL13172 IC50 = 160000.0 nM -
CHEMBL13210 IC50 = 2170000.0 nM -
CHEMBL12990 IC50 = 200000.0 nM -
CHEMBL13112 IC50 = 130000.0 nM -