Assay Detail
Binding
CHEMBL824491
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Binding affinity measured against Chicken brain melatonin receptor by using 2-[125I]iodomelatonin as radioligand
19
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of benzocycloalkane derivatives as new conformationally restricted ligands for melatonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.05 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111866 | — | — | 1 | 9.35 |
| CHEMBL113859 | — | — | 3 | 9.35 |
| CHEMBL111558 | — | — | 1 | 9.27 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.15 |
| CHEMBL111879 | — | — | 1 | 9.00 |
| CHEMBL113244 | — | — | 3 | 8.52 |
| CHEMBL113067 | — | — | 1 | 8.40 |
| CHEMBL113243 | — | — | 1 | 8.12 |
| CHEMBL111880 | — | — | 1 | 7.54 |
| CHEMBL320136 | — | — | 1 | 7.47 |
| CHEMBL114929 | — | — | 1 | 7.40 |
| CHEMBL112164 | — | — | 1 | 7.31 |
| CHEMBL111667 | — | — | 1 | 7.11 |
| CHEMBL53015 | — | — | 1 | 6.79 |
| CHEMBL419939 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111866 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL113859 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL113859 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL111558 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL45 | MELATONIN | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL111879 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL113244 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL113067 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL113243 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL113244 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL111880 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL320136 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL114929 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL112164 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL111667 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL53015 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL419939 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL113244 | — | Ki | = | 456.0 | nM | 6.34 |
| CHEMBL113859 | — | Ki | > | 1000.0 | nM | - |