Assay Detail
Binding
CHEMBL824640
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranes
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.13 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45129 | — | — | 1 | 9.10 |
| CHEMBL33868 | — | — | 1 | 8.92 |
| CHEMBL296857 | — | — | 1 | 8.92 |
| CHEMBL45961 | — | — | 1 | 8.85 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 8.85 |
| CHEMBL47544 | — | — | 1 | 8.82 |
| CHEMBL47739 | — | — | 1 | 8.77 |
| CHEMBL47713 | — | — | 1 | 8.74 |
| CHEMBL47775 | — | — | 1 | 8.72 |
| CHEMBL44722 | — | — | 1 | 8.66 |
| CHEMBL295059 | — | — | 1 | 8.48 |
| CHEMBL47412 | — | — | 1 | 8.47 |
| CHEMBL47179 | — | — | 1 | 8.34 |
| CHEMBL47408 | — | — | 1 | 8.33 |
| CHEMBL47275 | — | — | 1 | 8.15 |
| CHEMBL432301 | — | — | 1 | 7.51 |
| CHEMBL295770 | — | — | 1 | 6.71 |
| CHEMBL296122 | — | — | 1 | 6.34 |
| CHEMBL297086 | — | — | 1 | 5.92 |
| CHEMBL45362 | — | — | 1 | 5.90 |
| CHEMBL47555 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45129 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL33868 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL296857 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL45961 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL10188 | TALNETANT | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL47544 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL47739 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL47713 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL47775 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL44722 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL295059 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL47412 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL47179 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL47408 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL47275 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL432301 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL295770 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL296122 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL297086 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL45362 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL47555 | — | Ki | > | 12000.0 | nM | - |