Assay Detail
Binding
CHEMBL824729
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant cyclin B-CDK1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.27 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143748 | — | — | 1 | 6.27 |
| CHEMBL336242 | — | — | 1 | 5.75 |
| CHEMBL359020 | — | — | 1 | 4.55 |
| CHEMBL143285 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143748 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL336242 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL359020 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL143285 | — | IC50 | = | 31000.0 | nM | 4.51 |