Assay Detail
Functional
CHEMBL824878
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Inhibitory concentration against CEM cell growth after incubation in liquid medium for 72 h
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.84 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.08 |
| CHEMBL373114 | LAMELLARIN D | — | 1 | 8.30 |
| CHEMBL373113 | — | — | 1 | 7.77 |
| CHEMBL370322 | — | — | 1 | 6.37 |
| CHEMBL194663 | — | — | 1 | 6.28 |
| CHEMBL370730 | — | — | 1 | 5.71 |
| CHEMBL191994 | — | — | 1 | 5.65 |
| CHEMBL365388 | — | — | 1 | 5.52 |
| CHEMBL195359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL373114 | LAMELLARIN D | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL373113 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL370322 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL194663 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL370730 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL191994 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL365388 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL195359 | — | IC50 | > | 100000.0 | nM | - |