Assay Detail
Functional
CHEMBL824918
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Cytotoxic effect on A431 cell proliferation after 72 hr
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.79 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153231 | — | — | 1 | 9.30 |
| CHEMBL364180 | — | — | 1 | 8.55 |
| CHEMBL427327 | — | — | 1 | 8.52 |
| CHEMBL183521 | — | — | 1 | - |
| CHEMBL427593 | — | — | 1 | - |
| CHEMBL364396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153231 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL364180 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL427327 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL183521 | — | IC50 | > | 3.0 | nM | - |
| CHEMBL427593 | — | IC50 | > | 3.0 | nM | - |
| CHEMBL364396 | — | IC50 | > | 3.0 | nM | - |