Assay Detail
Functional
CHEMBL824928
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Inhibitory concentration against CEM/C2 cell growth after incubation in liquid medium for 72 h
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM/C2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.45 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373114 | LAMELLARIN D | — | 1 | 6.14 |
| CHEMBL370322 | — | — | 1 | 6.02 |
| CHEMBL373113 | — | — | 1 | 5.56 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.27 |
| CHEMBL365388 | — | — | 1 | 5.26 |
| CHEMBL194663 | — | — | 1 | 5.20 |
| CHEMBL370730 | — | — | 1 | 5.16 |
| CHEMBL191994 | — | — | 1 | 4.96 |
| CHEMBL195359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373114 | LAMELLARIN D | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL370322 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL373113 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5385.0 | nM | 5.27 |
| CHEMBL365388 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL194663 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL370730 | — | IC50 | = | 6930.0 | nM | 5.16 |
| CHEMBL191994 | — | IC50 | = | 11050.0 | nM | 4.96 |
| CHEMBL195359 | — | IC50 | > | 100000.0 | nM | - |