Assay Detail
Functional
CHEMBL826108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing human H3 receptor
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 7.91 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | — | 1 | 9.90 |
| CHEMBL175782 | METHIMEPIP | — | 1 | 9.50 |
| CHEMBL179302 | — | — | 1 | 8.60 |
| CHEMBL356666 | — | — | 1 | 8.50 |
| CHEMBL176178 | — | — | 1 | 8.40 |
| CHEMBL176269 | — | — | 1 | 8.40 |
| CHEMBL179873 | — | — | 1 | 8.10 |
| CHEMBL176105 | — | — | 1 | 8.10 |
| CHEMBL150701 | — | — | 1 | 7.90 |
| CHEMBL179479 | — | — | 1 | 7.80 |
| CHEMBL369819 | — | — | 1 | 7.80 |
| CHEMBL175741 | — | — | 1 | 7.60 |
| CHEMBL369096 | — | — | 1 | 7.50 |
| CHEMBL175800 | — | — | 1 | 7.30 |
| CHEMBL177612 | — | — | 1 | 7.30 |
| CHEMBL368774 | — | — | 1 | 7.20 |
| CHEMBL179747 | — | — | 1 | 7.10 |
| CHEMBL180061 | — | — | 1 | 6.70 |
| CHEMBL369158 | — | — | 1 | 6.50 |
| CHEMBL176608 | — | — | 1 | - |
| CHEMBL175771 | — | — | 1 | - |
| CHEMBL176018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | EC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL175782 | METHIMEPIP | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL179302 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL356666 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL176178 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL176269 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL179873 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL176105 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL150701 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL179479 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL369819 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL175741 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL369096 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL175800 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL177612 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL368774 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL179747 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL180061 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL369158 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL176608 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL175771 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL176018 | — | EC50 | < | 10000.0 | nM | - |