Assay Detail
Binding
CHEMBL826376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DHT from androgen receptor of human MDA-453 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-453 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.17 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185880 | — | — | 1 | 9.00 |
| CHEMBL188297 | — | — | 1 | 8.30 |
| CHEMBL365650 | — | — | 1 | 8.00 |
| CHEMBL426623 | — | — | 1 | 8.00 |
| CHEMBL362566 | — | — | 1 | 8.00 |
| CHEMBL187605 | — | — | 1 | 7.40 |
| CHEMBL365921 | — | — | 1 | 7.40 |
| CHEMBL188129 | — | — | 1 | 7.22 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | 7.19 |
| CHEMBL365482 | — | — | 1 | 7.16 |
| CHEMBL371392 | — | — | 1 | 7.00 |
| CHEMBL189600 | — | — | 1 | 6.92 |
| CHEMBL414845 | — | — | 1 | 6.75 |
| CHEMBL188857 | — | — | 1 | 6.72 |
| CHEMBL364393 | — | — | 1 | 6.64 |
| CHEMBL188803 | — | — | 1 | 6.62 |
| CHEMBL447184 | — | — | 1 | 6.16 |
| CHEMBL188545 | — | — | 1 | 5.99 |
| CHEMBL188261 | — | — | 1 | 5.85 |
| CHEMBL188681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185880 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL188297 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL365650 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL426623 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL362566 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL187605 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL365921 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL188129 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL409 | BICALUTAMIDE | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL365482 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL371392 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL189600 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL414845 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL188857 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL364393 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL188803 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL447184 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL188545 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL188261 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL188681 | — | Ki | > | 5000.0 | nM | - |