Assay Detail
Binding
CHEMBL826971
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Binding affinity for human estrogen receptor alpha
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.57 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183333 | — | — | 1 | 9.22 |
| CHEMBL304552 | — | — | 1 | 9.10 |
| CHEMBL328190 | LASOFOXIFENE | 4.0 | 1 | 8.89 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.89 |
| CHEMBL183162 | — | — | 1 | 8.62 |
| CHEMBL180085 | — | — | 1 | 7.89 |
| CHEMBL179929 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183333 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL304552 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL328190 | LASOFOXIFENE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL183162 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL180085 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL179929 | — | IC50 | = | 39.0 | nM | 7.41 |