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Assay Detail

CHEMBL826982

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Dissociation constant for ERK2 kinase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Mitogen-activated protein kinase 1 (CHEMBL4040)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of novel extracellular signal-regulated kinase docking domain inhibitors.
Hancock CN, Macias A, Lee EK, Yu SY, Mackerell AD, Shapiro P.
J Med Chem (2005) 48 : 4586 -4595
PubMed 15999996 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 3 5.13 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL364953 1 5.30
CHEMBL363555 1 5.30
CHEMBL190710 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL364953 Kd = 5000.0 nM 5.30
CHEMBL363555 Kd = 5000.0 nM 5.30
CHEMBL190710 Kd = 16000.0 nM 4.80