Assay Detail
Binding
CHEMBL826985
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Equilibrium binding constant for EPH receptor B2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 4.88 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127907 | — | — | 1 | 5.62 |
| CHEMBL150315 | — | — | 1 | 5.21 |
| CHEMBL10 | SB-203580 | — | 1 | 5.17 |
| CHEMBL29197 | — | — | 1 | 5.09 |
| CHEMBL66031 | — | — | 1 | 4.82 |
| CHEMBL296455 | — | — | 1 | 4.71 |
| CHEMBL92812 | — | — | 1 | 4.66 |
| CHEMBL406845 | — | — | 1 | 4.44 |
| CHEMBL97771 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127907 | — | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL150315 | — | Kd | = | 6200.0 | nM | 5.21 |
| CHEMBL10 | SB-203580 | Kd | = | 6800.0 | nM | 5.17 |
| CHEMBL29197 | — | Kd | = | 8100.0 | nM | 5.09 |
| CHEMBL66031 | — | Kd | = | 15200.0 | nM | 4.82 |
| CHEMBL296455 | — | Kd | = | 19500.0 | nM | 4.71 |
| CHEMBL92812 | — | Kd | = | 21900.0 | nM | 4.66 |
| CHEMBL406845 | — | Kd | = | 36500.0 | nM | 4.44 |
| CHEMBL97771 | — | Kd | = | 58400.0 | nM | 4.23 |