Assay Detail
Binding
CHEMBL827048
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Inhibitory activity against human TRAFalpha
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.11 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192142 | — | — | 1 | 6.38 |
| CHEMBL192427 | — | — | 1 | 6.28 |
| CHEMBL195556 | — | — | 1 | 6.22 |
| CHEMBL192639 | — | — | 1 | 6.16 |
| CHEMBL425366 | — | — | 1 | 6.09 |
| CHEMBL193198 | — | — | 1 | 5.96 |
| CHEMBL157885 | — | — | 1 | 5.66 |
| CHEMBL425557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192142 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL192427 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL195556 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL192639 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL425366 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL193198 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL157885 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL425557 | — | IC50 | > | 10000.0 | nM | - |