Assay Detail
Binding
CHEMBL827063
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Inhibitory constant against human Carbonic anhydrase I
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 6.59 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.51 |
| CHEMBL190024 | — | — | 1 | 7.51 |
| CHEMBL189526 | — | — | 1 | 7.48 |
| CHEMBL191045 | — | — | 1 | 7.46 |
| CHEMBL190733 | — | — | 1 | 7.41 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL190023 | — | — | 1 | 7.20 |
| CHEMBL189523 | — | — | 1 | 7.12 |
| CHEMBL192834 | — | — | 1 | 7.12 |
| CHEMBL363874 | — | — | 1 | 7.06 |
| CHEMBL190550 | — | — | 1 | 7.03 |
| CHEMBL364754 | — | — | 1 | 7.02 |
| CHEMBL191380 | — | — | 1 | 6.98 |
| CHEMBL190721 | — | — | 1 | 6.98 |
| CHEMBL364919 | — | — | 1 | 6.95 |
| CHEMBL371403 | — | — | 1 | 6.95 |
| CHEMBL193178 | — | — | 1 | 6.89 |
| CHEMBL191576 | — | — | 1 | 6.89 |
| CHEMBL440026 | — | — | 1 | 6.81 |
| CHEMBL190907 | — | — | 1 | 6.75 |
| CHEMBL190538 | — | — | 1 | 6.75 |
| CHEMBL189681 | — | — | 1 | 6.70 |
| CHEMBL366223 | — | — | 1 | 6.63 |
| CHEMBL189527 | — | — | 1 | 6.62 |
| CHEMBL191884 | — | — | 1 | 6.61 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL193513 | — | — | 1 | 6.43 |
| CHEMBL434909 | — | — | 1 | 6.37 |
| CHEMBL192950 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL77517 | INDISULAM | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL190024 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL189526 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL191045 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL190733 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL190023 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL189523 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL192834 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL363874 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL190550 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL364754 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL191380 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL190721 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL364919 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL371403 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL193178 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL191576 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL440026 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL190907 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL190538 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL189681 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL366223 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL189527 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL191884 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL193513 | — | Ki | = | 368.0 | nM | 6.43 |
| CHEMBL434909 | — | Ki | = | 425.0 | nM | 6.37 |
| CHEMBL192950 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL190464 | — | Ki | = | 549.0 | nM | 6.26 |
| CHEMBL190278 | — | Ki | = | 558.0 | nM | 6.25 |
| CHEMBL190531 | — | Ki | = | 561.0 | nM | 6.25 |
| CHEMBL371632 | — | Ki | = | 622.0 | nM | 6.21 |
| CHEMBL190056 | — | Ki | = | 613.0 | nM | 6.21 |
| CHEMBL366276 | — | Ki | = | 631.0 | nM | 6.20 |
| CHEMBL372442 | — | Ki | = | 875.0 | nM | 6.06 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL190329 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL426625 | — | Ki | = | 1635.0 | nM | 5.79 |
| CHEMBL365380 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL192670 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL193008 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |