Assay Detail
Binding
CHEMBL827064
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Inhibitory constant against human Carbonic anhydrase I
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.25 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL167179 | — | — | 1 | 8.10 |
| CHEMBL166340 | — | — | 1 | 7.70 |
| CHEMBL169486 | — | — | 1 | 7.47 |
| CHEMBL168910 | — | — | 1 | 7.41 |
| CHEMBL67749 | — | — | 1 | 6.99 |
| CHEMBL303601 | — | — | 1 | 6.43 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | — | 1 | 6.38 |
| CHEMBL24119 | — | — | 1 | 6.32 |
| CHEMBL195540 | — | — | 1 | 5.39 |
| CHEMBL193635 | — | — | 1 | 5.24 |
| CHEMBL195370 | — | — | 1 | 5.22 |
| CHEMBL193396 | — | — | 1 | 5.09 |
| CHEMBL370104 | — | — | 1 | 5.09 |
| CHEMBL305268 | METHANESULFONAMIDE | — | 1 | 4.68 |
| CHEMBL355001 | SULFAMIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL167179 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL166340 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL169486 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL168910 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL67749 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL303601 | — | Ki | = | 369.0 | nM | 6.43 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL24119 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL195540 | — | Ki | = | 4050.0 | nM | 5.39 |
| CHEMBL193635 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL195370 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL193396 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL370104 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL305268 | METHANESULFONAMIDE | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL355001 | SULFAMIDE | Ki | = | 310000.0 | nM | - |