Assay Detail
Binding
CHEMBL827065
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Inhibitory constant against human Carbonic anhydrase I
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.70 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195811 | — | — | 1 | 8.51 |
| CHEMBL196198 | — | — | 1 | 8.43 |
| CHEMBL365344 | — | — | 1 | 8.07 |
| CHEMBL362989 | — | — | 1 | 8.02 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.51 |
| CHEMBL7146 | — | — | 1 | 7.02 |
| CHEMBL364081 | — | — | 1 | 6.98 |
| CHEMBL266026 | — | — | 1 | 6.96 |
| CHEMBL269122 | — | — | 1 | 6.79 |
| CHEMBL195509 | — | — | 1 | 6.76 |
| CHEMBL193964 | — | — | 1 | 6.68 |
| CHEMBL195147 | — | — | 1 | 6.63 |
| CHEMBL195194 | — | — | 1 | 6.61 |
| CHEMBL195978 | — | — | 1 | 6.57 |
| CHEMBL196285 | — | — | 1 | 6.51 |
| CHEMBL196435 | — | — | 1 | 6.45 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL7087 | — | — | 1 | 4.68 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 4.60 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195811 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL196198 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL365344 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL362989 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL77517 | INDISULAM | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL7146 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL364081 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL266026 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL269122 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL195509 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL193964 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL195147 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL195194 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL195978 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL196285 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL196435 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL7087 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL419 | MAFENIDE | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 28000.0 | nM | 4.55 |