Assay Detail
Binding
CHEMBL827188
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Low inhibition constant against [3H]spiperone binding to human Dopamine receptor D4.4 expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.20 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 7.28 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 6.89 |
| CHEMBL316983 | — | — | 1 | 5.60 |
| CHEMBL372020 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL301265 | PRAMIPEXOLE | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL316983 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL372020 | — | Ki | = | 9700.0 | nM | 5.01 |