Assay Detail
Binding
CHEMBL827388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human Carbonic anhydrase IX
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.04 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161632 | BICARBONATE | 3.0 | 1 | 5.07 |
| CHEMBL68253 | SULFAMATE | — | 1 | 5.04 |
| CHEMBL355001 | SULFAMIDE | — | 1 | 5.02 |
| CHEMBL1161637 | PERIODATE | — | 1 | - |
| CHEMBL2068408 | SILICATE | 2.0 | 1 | - |
| CHEMBL2068407 | BISMUTHATE | -1.0 | 1 | - |
| CHEMBL86473 | VANADATE | — | 1 | - |
| CHEMBL1851809 | MOLIBDATE | — | 1 | - |
| CHEMBL2010348 | WOLFRAMATE | — | 1 | - |
| CHEMBL572964 | SULFURIC ACID | -1.0 | 1 | - |
| CHEMBL1352 | NITRIC ACID | 3.0 | 1 | - |
| CHEMBL1161633 | CHLORATE | — | 1 | - |
| CHEMBL1161634 | PERCHLORATE | — | 1 | - |
| CHEMBL1161635 | BROMATE | — | 1 | - |
| CHEMBL1161636 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161632 | BICARBONATE | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL68253 | SULFAMATE | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL355001 | SULFAMIDE | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL1161637 | PERIODATE | Ki | = | 30300000.0 | nM | - |
| CHEMBL2068408 | SILICATE | Ki | = | 2750000.0 | nM | - |
| CHEMBL2068407 | BISMUTHATE | Ki | = | 22800000.0 | nM | - |
| CHEMBL86473 | VANADATE | Ki | = | 42600000.0 | nM | - |
| CHEMBL1851809 | MOLIBDATE | Ki | = | 24700000.0 | nM | - |
| CHEMBL2010348 | WOLFRAMATE | Ki | = | 23900000.0 | nM | - |
| CHEMBL572964 | SULFURIC ACID | Ki | = | 154000000.0 | nM | - |
| CHEMBL1352 | NITRIC ACID | Ki | = | 46000000.0 | nM | - |
| CHEMBL1161633 | CHLORATE | Ki | = | 147000000.0 | nM | - |
| CHEMBL1161634 | PERCHLORATE | Ki | = | 11600000.0 | nM | - |
| CHEMBL1161635 | BROMATE | Ki | = | 274000000.0 | nM | - |
| CHEMBL1161636 | — | Ki | = | 49700000.0 | nM | - |