Assay Detail
Binding
CHEMBL827432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radioligand [125I]AB-MECA binding at rat A3 receptor expressed in CHO cells
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
BCUT descriptors to predicting affinity toward A3 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 6.64 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265587 | — | — | 1 | 8.01 |
| CHEMBL203933 | — | — | 1 | 7.79 |
| CHEMBL204820 | — | — | 1 | 7.77 |
| CHEMBL203812 | — | — | 1 | 7.68 |
| CHEMBL426847 | — | — | 1 | 7.42 |
| CHEMBL610326 | — | — | 1 | 7.27 |
| CHEMBL380914 | — | — | 1 | 7.11 |
| CHEMBL203667 | — | — | 1 | 7.05 |
| CHEMBL610394 | — | — | 1 | 6.97 |
| CHEMBL383268 | — | — | 1 | 6.83 |
| CHEMBL204190 | — | — | 1 | 6.81 |
| CHEMBL1791443 | — | — | 1 | 6.81 |
| CHEMBL203958 | — | — | 1 | 6.78 |
| CHEMBL383548 | — | — | 1 | 6.78 |
| CHEMBL413046 | — | — | 1 | 6.68 |
| CHEMBL379472 | — | — | 1 | 6.60 |
| CHEMBL437503 | — | — | 1 | 6.50 |
| CHEMBL204246 | — | — | 1 | 6.50 |
| CHEMBL203960 | — | — | 1 | 6.49 |
| CHEMBL204651 | — | — | 1 | 6.39 |
| CHEMBL609340 | — | — | 1 | 6.39 |
| CHEMBL202690 | — | — | 1 | 6.27 |
| CHEMBL206265 | — | — | 1 | 6.24 |
| CHEMBL381917 | — | — | 1 | 6.21 |
| CHEMBL206116 | — | — | 1 | 6.16 |
| CHEMBL377291 | — | — | 1 | 6.15 |
| CHEMBL437506 | — | — | 1 | 6.12 |
| CHEMBL205058 | — | — | 1 | 6.08 |
| CHEMBL426669 | — | — | 1 | 6.08 |
| CHEMBL202722 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265587 | — | Ki | = | 9.73 | nM | 8.01 |
| CHEMBL203933 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL204820 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL203812 | — | Ki | = | 20.9 | nM | 7.68 |
| CHEMBL426847 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL610326 | — | Ki | = | 54.1 | nM | 7.27 |
| CHEMBL380914 | — | Ki | = | 77.6 | nM | 7.11 |
| CHEMBL203667 | — | Ki | = | 89.5 | nM | 7.05 |
| CHEMBL610394 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL383268 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL204190 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL1791443 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL203958 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL383548 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL413046 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL379472 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL437503 | — | Ki | = | 319.0 | nM | 6.50 |
| CHEMBL204246 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL203960 | — | Ki | = | 324.0 | nM | 6.49 |
| CHEMBL204651 | — | Ki | = | 411.0 | nM | 6.39 |
| CHEMBL609340 | — | Ki | = | 405.0 | nM | 6.39 |
| CHEMBL202690 | — | Ki | = | 532.0 | nM | 6.27 |
| CHEMBL206265 | — | Ki | = | 581.0 | nM | 6.24 |
| CHEMBL381917 | — | Ki | = | 611.0 | nM | 6.21 |
| CHEMBL206116 | — | Ki | = | 696.0 | nM | 6.16 |
| CHEMBL377291 | — | Ki | = | 713.0 | nM | 6.15 |
| CHEMBL437506 | — | Ki | = | 754.0 | nM | 6.12 |
| CHEMBL205058 | — | Ki | = | 837.0 | nM | 6.08 |
| CHEMBL426669 | — | Ki | = | 824.0 | nM | 6.08 |
| CHEMBL202722 | — | Ki | = | 979.0 | nM | 6.01 |
| CHEMBL437315 | — | Ki | = | 5550.0 | nM | 5.26 |
| CHEMBL202249 | — | Ki | = | 5700.0 | nM | 5.24 |