Assay Detail
Binding
CHEMBL827434
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Binding affinity towards adrenergic alpha-1 receptor from porcine cortical membranes using [3H]-prazosin
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.55 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182652 | — | — | 1 | 8.77 |
| CHEMBL184993 | — | — | 1 | 8.24 |
| CHEMBL182379 | — | — | 1 | 8.23 |
| CHEMBL362101 | — | — | 1 | 7.38 |
| CHEMBL183871 | — | — | 1 | 7.31 |
| CHEMBL184383 | — | — | 1 | 6.52 |
| CHEMBL59725 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182652 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL184993 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL182379 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL362101 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL183871 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL184383 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL59725 | — | Ki | = | 370.0 | nM | 6.43 |