Assay Detail
Functional
CHEMBL827468
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Antioxidant activity against formation of ROS was determined in t-BuOOH treated LNCaP cells after 24 hr of incubation with compounds (1-100 uM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.64 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179743 | — | — | 1 | 5.58 |
| CHEMBL134342 | THIOCTIC ACID | — | 1 | 4.26 |
| CHEMBL178923 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179743 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL134342 | THIOCTIC ACID | IC50 | = | 54860.0 | nM | 4.26 |
| CHEMBL178923 | — | IC50 | = | 83530.0 | nM | 4.08 |