Assay Detail
Binding
CHEMBL827657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of inducible nitric oxide synthase in activated macrophages
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.45 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093059 | BARDOXOLONE | 2.0 | 1 | 9.70 |
| CHEMBL196027 | — | — | 1 | 7.40 |
| CHEMBL1765578 | — | — | 1 | 6.70 |
| CHEMBL195352 | — | — | 1 | 6.22 |
| CHEMBL194396 | — | — | 1 | 5.48 |
| CHEMBL196236 | — | — | 1 | 5.25 |
| CHEMBL470029 | OLEANONIC ACID | — | 1 | 4.43 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL196027 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1765578 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL195352 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL194396 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL196236 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL470029 | OLEANONIC ACID | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 40000.0 | nM | - |