Assay Detail
Functional
CHEMBL827680
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Effective concentration against PI-Resistant HIV strain (M1)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.23 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.29 |
| CHEMBL176823 | — | — | 1 | 8.12 |
| CHEMBL469086 | — | — | 1 | 7.99 |
| CHEMBL177418 | — | — | 1 | 7.63 |
| CHEMBL366784 | — | — | 1 | 7.50 |
| CHEMBL178593 | — | — | 1 | 7.49 |
| CHEMBL360661 | — | — | 1 | 7.48 |
| CHEMBL175861 | — | — | 1 | 7.47 |
| CHEMBL175231 | — | — | 1 | 7.43 |
| CHEMBL366830 | — | — | 1 | 6.94 |
| CHEMBL359662 | — | — | 1 | 6.89 |
| CHEMBL176379 | — | — | 1 | 6.78 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.13 |
| CHEMBL176275 | — | — | 1 | 6.12 |
| CHEMBL179266 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | EC50 | = | 5.129 | nM | 8.29 |
| CHEMBL176823 | — | EC50 | = | 7.586 | nM | 8.12 |
| CHEMBL469086 | — | EC50 | = | 10.23 | nM | 7.99 |
| CHEMBL177418 | — | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL366784 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL178593 | — | EC50 | = | 32.36 | nM | 7.49 |
| CHEMBL360661 | — | EC50 | = | 33.11 | nM | 7.48 |
| CHEMBL175861 | — | EC50 | = | 33.88 | nM | 7.47 |
| CHEMBL175231 | — | EC50 | = | 37.15 | nM | 7.43 |
| CHEMBL366830 | — | EC50 | = | 114.82 | nM | 6.94 |
| CHEMBL359662 | — | EC50 | = | 128.82 | nM | 6.89 |
| CHEMBL176379 | — | EC50 | = | 165.96 | nM | 6.78 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 741.31 | nM | 6.13 |
| CHEMBL176275 | — | EC50 | = | 758.58 | nM | 6.12 |
| CHEMBL179266 | — | EC50 | = | 758.58 | nM | 6.12 |