Assay Detail
Functional
CHEMBL827683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against PI-Resistant HIV strain (M4)
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.61 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 2 | 8.41 |
| CHEMBL178593 | — | — | 1 | 8.40 |
| CHEMBL469086 | — | — | 1 | 8.33 |
| CHEMBL360661 | — | — | 1 | 8.28 |
| CHEMBL177418 | — | — | 1 | 8.22 |
| CHEMBL176823 | — | — | 1 | 8.18 |
| CHEMBL175231 | — | — | 1 | 7.67 |
| CHEMBL175861 | — | — | 1 | 7.66 |
| CHEMBL176275 | — | — | 1 | 7.58 |
| CHEMBL359662 | — | — | 1 | 7.42 |
| CHEMBL176379 | — | — | 1 | 7.38 |
| CHEMBL366830 | — | — | 1 | 7.05 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.77 |
| CHEMBL179266 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | EC50 | = | 3.89 | nM | 8.41 |
| CHEMBL178593 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL469086 | — | EC50 | = | 4.677 | nM | 8.33 |
| CHEMBL360661 | — | EC50 | = | 5.248 | nM | 8.28 |
| CHEMBL177418 | — | EC50 | = | 6.026 | nM | 8.22 |
| CHEMBL176823 | — | EC50 | = | 6.607 | nM | 8.18 |
| CHEMBL175231 | — | EC50 | = | 21.38 | nM | 7.67 |
| CHEMBL175861 | — | EC50 | = | 21.88 | nM | 7.66 |
| CHEMBL176275 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL359662 | — | EC50 | = | 38.02 | nM | 7.42 |
| CHEMBL176379 | — | EC50 | = | 41.69 | nM | 7.38 |
| CHEMBL366830 | — | EC50 | = | 89.13 | nM | 7.05 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 144.54 | nM | 6.84 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL179266 | — | EC50 | = | 1122.02 | nM | 5.95 |