Assay Detail
Functional
CHEMBL827684
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Effective concentration against PI-Resistant HIV strain (M5)
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.68 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469086 | — | — | 1 | 8.54 |
| CHEMBL178593 | — | — | 1 | 8.39 |
| CHEMBL360661 | — | — | 1 | 8.30 |
| CHEMBL176823 | — | — | 1 | 8.25 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 2 | 8.22 |
| CHEMBL177418 | — | — | 1 | 8.21 |
| CHEMBL366784 | — | — | 1 | 7.93 |
| CHEMBL176275 | — | — | 1 | 7.58 |
| CHEMBL175231 | — | — | 1 | 7.58 |
| CHEMBL176379 | — | — | 1 | 7.51 |
| CHEMBL359662 | — | — | 1 | 7.39 |
| CHEMBL175861 | — | — | 1 | 7.34 |
| CHEMBL366830 | — | — | 1 | 6.86 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469086 | — | EC50 | = | 2.884 | nM | 8.54 |
| CHEMBL178593 | — | EC50 | = | 4.074 | nM | 8.39 |
| CHEMBL360661 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL176823 | — | EC50 | = | 5.623 | nM | 8.25 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 6.026 | nM | 8.22 |
| CHEMBL177418 | — | EC50 | = | 6.166 | nM | 8.21 |
| CHEMBL366784 | — | EC50 | = | 11.75 | nM | 7.93 |
| CHEMBL176275 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL175231 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL176379 | — | EC50 | = | 30.9 | nM | 7.51 |
| CHEMBL359662 | — | EC50 | = | 40.74 | nM | 7.39 |
| CHEMBL175861 | — | EC50 | = | 45.71 | nM | 7.34 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL366830 | — | EC50 | = | 138.04 | nM | 6.86 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 741.31 | nM | 6.13 |