Assay Detail
Functional
CHEMBL827685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration of against HIV Wild Type (IIIB) strain
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 8.16 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469086 | — | — | 1 | 9.23 |
| CHEMBL178593 | — | — | 1 | 9.21 |
| CHEMBL360661 | — | — | 1 | 8.82 |
| CHEMBL366784 | — | — | 1 | 8.71 |
| CHEMBL175861 | — | — | 1 | 8.61 |
| CHEMBL176379 | — | — | 1 | 8.56 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 2 | 8.39 |
| CHEMBL176275 | — | — | 1 | 8.36 |
| CHEMBL366830 | — | — | 1 | 8.28 |
| CHEMBL359662 | — | — | 1 | 8.28 |
| CHEMBL177418 | — | — | 1 | 8.20 |
| CHEMBL176823 | — | — | 1 | 8.15 |
| CHEMBL175231 | — | — | 1 | 7.97 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.43 |
| CHEMBL179266 | — | — | 1 | 6.62 |
| CHEMBL262307 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469086 | — | EC50 | = | 0.5888 | nM | 9.23 |
| CHEMBL178593 | — | EC50 | = | 0.6166 | nM | 9.21 |
| CHEMBL360661 | — | EC50 | = | 1.514 | nM | 8.82 |
| CHEMBL366784 | — | EC50 | = | 1.95 | nM | 8.71 |
| CHEMBL175861 | — | EC50 | = | 2.455 | nM | 8.61 |
| CHEMBL176379 | — | EC50 | = | 2.754 | nM | 8.56 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 4.074 | nM | 8.39 |
| CHEMBL176275 | — | EC50 | = | 4.365 | nM | 8.36 |
| CHEMBL366830 | — | EC50 | = | 5.248 | nM | 8.28 |
| CHEMBL359662 | — | EC50 | = | 5.248 | nM | 8.28 |
| CHEMBL177418 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL176823 | — | EC50 | = | 7.079 | nM | 8.15 |
| CHEMBL175231 | — | EC50 | = | 10.72 | nM | 7.97 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 37.15 | nM | 7.43 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 43.65 | nM | 7.36 |
| CHEMBL179266 | — | EC50 | = | 239.88 | nM | 6.62 |
| CHEMBL262307 | — | EC50 | = | 309.03 | nM | 6.51 |