Assay Detail
Functional
CHEMBL827686
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Effective concentration as average activity on mutant HIV panel (AVMUT)
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.51 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469086 | — | — | 1 | 8.35 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 2 | 8.29 |
| CHEMBL178593 | — | — | 1 | 8.19 |
| CHEMBL176823 | — | — | 1 | 8.11 |
| CHEMBL177418 | — | — | 1 | 8.06 |
| CHEMBL360661 | — | — | 1 | 8.06 |
| CHEMBL366784 | — | — | 1 | 7.86 |
| CHEMBL175861 | — | — | 1 | 7.67 |
| CHEMBL175231 | — | — | 1 | 7.51 |
| CHEMBL176275 | — | — | 1 | 7.37 |
| CHEMBL359662 | — | — | 1 | 7.22 |
| CHEMBL176379 | — | — | 1 | 7.17 |
| CHEMBL366830 | — | — | 1 | 7.01 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.49 |
| CHEMBL179266 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469086 | — | EC50 | = | 4.467 | nM | 8.35 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 5.129 | nM | 8.29 |
| CHEMBL178593 | — | EC50 | = | 6.457 | nM | 8.19 |
| CHEMBL176823 | — | EC50 | = | 7.762 | nM | 8.11 |
| CHEMBL177418 | — | EC50 | = | 8.71 | nM | 8.06 |
| CHEMBL360661 | — | EC50 | = | 8.71 | nM | 8.06 |
| CHEMBL366784 | — | EC50 | = | 13.8 | nM | 7.86 |
| CHEMBL175861 | — | EC50 | = | 21.38 | nM | 7.67 |
| CHEMBL175231 | — | EC50 | = | 30.9 | nM | 7.51 |
| CHEMBL176275 | — | EC50 | = | 42.66 | nM | 7.37 |
| CHEMBL359662 | — | EC50 | = | 60.26 | nM | 7.22 |
| CHEMBL176379 | — | EC50 | = | 67.61 | nM | 7.17 |
| CHEMBL366830 | — | EC50 | = | 97.72 | nM | 7.01 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 323.59 | nM | 6.49 |
| CHEMBL179266 | — | EC50 | = | 977.24 | nM | 6.01 |