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Assay Detail

CHEMBL827707

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Binding
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
ChEMBL ↗
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1A (CHEMBL273) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Indolebutylamines as selective 5-HT(1A) agonists.
Heinrich T, Böttcher H, Bartoszyk GD, Greiner HE, Seyfried CA, Van Amsterdam C.
J Med Chem (2004) 47 : 4677 -4683
PubMed 15341483 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 52 8.71 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL186423 — — 1 11.00
CHEMBL364181 — — 1 10.15
CHEMBL360419 — — 1 10.05
CHEMBL185860 — — 1 10.00
CHEMBL189708 — — 1 10.00
CHEMBL188625 — — 1 10.00
CHEMBL365716 — — 1 10.00
CHEMBL439664 — — 1 9.70
CHEMBL189450 — — 1 9.70
CHEMBL364592 — — 1 9.70
CHEMBL186608 — — 1 9.52
CHEMBL189454 — — 1 9.40
CHEMBL363537 — — 1 9.40
CHEMBL186814 — — 1 9.40
CHEMBL186405 — — 1 9.40
CHEMBL186115 — — 1 9.30
CHEMBL188296 — — 1 9.30
CHEMBL363292 — — 1 9.30
CHEMBL185915 — — 1 9.30
CHEMBL366104 — — 1 9.22
CHEMBL366269 — — 1 9.15
CHEMBL431367 ROXINDOLE 2.0 1 9.10
CHEMBL362771 — — 1 9.10
CHEMBL188471 — — 1 9.10
CHEMBL185938 — — 1 9.05
CHEMBL360179 — — 1 9.05
CHEMBL363932 — — 1 9.00
CHEMBL185899 — — 1 9.00
CHEMBL359793 — — 1 8.70
CHEMBL186173 — — 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL186423 — IC50 = 0.01 nM 11.00
CHEMBL364181 — IC50 = 0.07 nM 10.15
CHEMBL360419 — IC50 = 0.09 nM 10.05
CHEMBL185860 — IC50 = 0.1 nM 10.00
CHEMBL189708 — IC50 = 0.1 nM 10.00
CHEMBL188625 — IC50 = 0.1 nM 10.00
CHEMBL365716 — IC50 = 0.1 nM 10.00
CHEMBL364592 — IC50 = 0.2 nM 9.70
CHEMBL439664 — IC50 = 0.2 nM 9.70
CHEMBL189450 — IC50 = 0.2 nM 9.70
CHEMBL186608 — IC50 = 0.3 nM 9.52
CHEMBL186814 — IC50 = 0.4 nM 9.40
CHEMBL186405 — IC50 = 0.4 nM 9.40
CHEMBL363537 — IC50 = 0.4 nM 9.40
CHEMBL189454 — IC50 = 0.4 nM 9.40
CHEMBL186115 — IC50 = 0.5 nM 9.30
CHEMBL185915 — IC50 = 0.5 nM 9.30
CHEMBL363292 — IC50 = 0.5 nM 9.30
CHEMBL188296 — IC50 = 0.5 nM 9.30
CHEMBL366104 — IC50 = 0.6 nM 9.22
CHEMBL366269 — IC50 = 0.7 nM 9.15
CHEMBL431367 ROXINDOLE IC50 = 0.8 nM 9.10
CHEMBL362771 — IC50 = 0.8 nM 9.10
CHEMBL188471 — IC50 = 0.8 nM 9.10
CHEMBL360179 — IC50 = 0.9 nM 9.05
CHEMBL185938 — IC50 = 0.9 nM 9.05
CHEMBL363932 — IC50 = 1.0 nM 9.00
CHEMBL185899 — IC50 = 1.0 nM 9.00
CHEMBL359793 — IC50 = 2.0 nM 8.70
CHEMBL186173 — IC50 = 2.0 nM 8.70
CHEMBL441501 — IC50 = 2.0 nM 8.70
CHEMBL185779 — IC50 = 2.0 nM 8.70
CHEMBL364150 — IC50 = 3.0 nM 8.52
CHEMBL187196 — IC50 = 4.0 nM 8.40
CHEMBL366271 — IC50 = 4.0 nM 8.40
CHEMBL360415 — IC50 = 8.0 nM 8.10
CHEMBL8412 IPSAPIRONE IC50 = 8.2 nM 8.09
CHEMBL186409 — IC50 = 10.0 nM 8.00
CHEMBL130327 — IC50 = 20.0 nM 7.70
CHEMBL186229 — IC50 = 20.0 nM 7.70
CHEMBL186034 — IC50 = 20.0 nM 7.70
CHEMBL186464 — IC50 = 24.0 nM 7.62
CHEMBL188408 — IC50 = 30.0 nM 7.52
CHEMBL186415 — IC50 = 34.0 nM 7.47
CHEMBL365433 — IC50 = 40.0 nM 7.40
CHEMBL188183 — IC50 = 40.0 nM 7.40
CHEMBL426616 — IC50 = 60.0 nM 7.22
CHEMBL184172 — IC50 = 70.0 nM 7.16
CHEMBL364341 — IC50 = 90.0 nM 7.05
CHEMBL188184 — IC50 = 100.0 nM 7.00