Assay Detail
Binding
CHEMBL827788
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Binding affinity for human Estrogen receptor Alpha
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.81 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30707 | COUMESTROL | — | 2 | 7.12 |
| CHEMBL193518 | — | — | 2 | 6.92 |
| CHEMBL192548 | — | — | 2 | 5.63 |
| CHEMBL44 | GENISTEIN | 2.0 | 2 | 5.33 |
| CHEMBL370039 | — | — | 2 | 4.07 |
| CHEMBL103 | PROGESTERONE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30707 | COUMESTROL | IC50 | = | 75.7 | nM | 7.12 |
| CHEMBL30707 | COUMESTROL | IC50 | = | 75.7 | nM | 7.12 |
| CHEMBL193518 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL193518 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL192548 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL192548 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL44 | GENISTEIN | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL44 | GENISTEIN | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL370039 | — | IC50 | = | 85700.0 | nM | 4.07 |
| CHEMBL370039 | — | IC50 | = | 85700.0 | nM | 4.07 |
| CHEMBL103 | PROGESTERONE | IC50 | > | 1000.0 | nM | - |
| CHEMBL103 | PROGESTERONE | IC50 | > | 1000.0 | nM | - |