Assay Detail
Binding
CHEMBL827828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5 lM Cbz-Phe-Arg-AMC bindign to human cathepsin L activity in fluorescence assay with 100 mM NaOAc
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.69 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234367 | — | — | 1 | 5.06 |
| CHEMBL186778 | — | — | 1 | 5.00 |
| CHEMBL191584 | — | — | 1 | 5.00 |
| CHEMBL426617 | — | — | 1 | 4.82 |
| CHEMBL189604 | — | — | 1 | 4.77 |
| CHEMBL188563 | — | — | 1 | 4.77 |
| CHEMBL188438 | — | — | 1 | 4.48 |
| CHEMBL190053 | — | — | 1 | 4.44 |
| CHEMBL191178 | — | — | 1 | 4.43 |
| CHEMBL188400 | — | — | 1 | 4.16 |
| CHEMBL363773 | — | — | 1 | - |
| CHEMBL186149 | — | — | 1 | - |
| CHEMBL189417 | — | — | 1 | - |
| CHEMBL365822 | — | — | 1 | - |
| CHEMBL188929 | — | — | 1 | - |
| CHEMBL187864 | — | — | 1 | - |
| CHEMBL365049 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234367 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL186778 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL191584 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL426617 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL189604 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL188563 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL188438 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL190053 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL191178 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL188400 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL363773 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL186149 | — | IC50 | = | 3800000.0 | nM | - |
| CHEMBL189417 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL365822 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL188929 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL187864 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL365049 | — | IC50 | = | 1000000.0 | nM | - |