Assay Detail
Binding
CHEMBL827830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 10 uM Cbz-Phe-Arg-AMC binding to human cathepsin K by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Ketoheterocycle-based inhibitors of cathepsin K: a novel entry into the synthesis of peptidic ketoheterocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.76 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116402 | — | — | 1 | 8.57 |
| CHEMBL361816 | — | — | 1 | 6.64 |
| CHEMBL183796 | — | — | 1 | 5.72 |
| CHEMBL361975 | — | — | 1 | 5.51 |
| CHEMBL360745 | — | — | 1 | 5.40 |
| CHEMBL181105 | — | — | 1 | 5.15 |
| CHEMBL360237 | — | — | 1 | 5.09 |
| CHEMBL182539 | — | — | 1 | 4.89 |
| CHEMBL434132 | — | — | 1 | 4.89 |
| CHEMBL359612 | — | — | 1 | - |
| CHEMBL183647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116402 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL361816 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL183796 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL361975 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL360745 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL181105 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL360237 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL182539 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL434132 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL359612 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL183647 | — | IC50 | > | 13000.0 | nM | - |