Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL827889

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteum
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prostaglandin F2-alpha receptor (CHEMBL4820)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey.
Selliah RD, Hellberg MR, Sharif NA, McLaughlin MA, Williams GW, Scott DA, Earnest D, Haggard KS, Dean WD, Delgado P, Gaines MS, Conrow RE, Klimko PG.
Bioorg Med Chem Lett (2004) 14 : 4525 -4528
PubMed 15357985 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 6.06 7.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL185484 1 7.28
CHEMBL364375 1 7.04
CHEMBL815 DINOPROST 4.0 1 6.89
CHEMBL183193 1 6.83
CHEMBL184249 1 6.48
CHEMBL185559 1 6.46
CHEMBL182117 1 6.19
CHEMBL433752 1 6.09
CHEMBL360862 1 6.05
CHEMBL273444 1 5.55
CHEMBL186192 1 5.51
CHEMBL363946 1 5.29
CHEMBL360869 1 5.17
CHEMBL184264 1 5.14
CHEMBL363439 1 5.00
CHEMBL264554 1 -
CHEMBL185466 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL185484 Ki = 52.0 nM 7.28
CHEMBL364375 Ki = 92.0 nM 7.04
CHEMBL815 DINOPROST Ki = 129.0 nM 6.89
CHEMBL183193 Ki = 147.0 nM 6.83
CHEMBL184249 Ki = 330.0 nM 6.48
CHEMBL185559 Ki = 350.0 nM 6.46
CHEMBL182117 Ki = 640.0 nM 6.19
CHEMBL433752 Ki = 820.0 nM 6.09
CHEMBL360862 Ki = 890.0 nM 6.05
CHEMBL273444 Ki = 2800.0 nM 5.55
CHEMBL186192 Ki = 3100.0 nM 5.51
CHEMBL363946 Ki = 5100.0 nM 5.29
CHEMBL360869 Ki = 6700.0 nM 5.17
CHEMBL184264 Ki = 7300.0 nM 5.14
CHEMBL363439 Ki = 9900.0 nM 5.00
CHEMBL264554 Ki > 10000.0 nM -
CHEMBL185466 Ki > 10000.0 nM -