Assay Detail
Binding
CHEMBL827892
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Inhibitory constant against thymidylate synthase from Lactobacillus casei
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.71 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360758 | — | — | 1 | 10.00 |
| CHEMBL362606 | — | — | 1 | 9.52 |
| CHEMBL360335 | — | — | 1 | 9.30 |
| CHEMBL179448 | — | — | 1 | 8.80 |
| CHEMBL425692 | — | — | 1 | 8.77 |
| CHEMBL176072 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360758 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL362606 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL360335 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL179448 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL425692 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL176072 | — | Ki | = | 1400.0 | nM | 5.85 |