Assay Detail
Binding
CHEMBL827894
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Inhibition of Cyclin-dependent kinase 4-cyclinD
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D (CHEMBL2095942) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.35 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365847 | — | — | 1 | 8.70 |
| CHEMBL190281 | — | — | 1 | 8.70 |
| CHEMBL370295 | — | — | 1 | 8.40 |
| CHEMBL190627 | — | — | 1 | 8.30 |
| CHEMBL189937 | — | — | 1 | 8.30 |
| CHEMBL193167 | — | — | 1 | 8.30 |
| CHEMBL190096 | — | — | 1 | 8.22 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 7.96 |
| CHEMBL193177 | — | — | 1 | 7.92 |
| CHEMBL373300 | — | — | 1 | 7.89 |
| CHEMBL192827 | — | — | 1 | 7.89 |
| CHEMBL189011 | — | — | 1 | 7.89 |
| CHEMBL193184 | — | — | 1 | 7.85 |
| CHEMBL192060 | — | — | 1 | 7.82 |
| CHEMBL192308 | — | — | 1 | 7.80 |
| CHEMBL371198 | — | — | 1 | 7.75 |
| CHEMBL415773 | — | — | 1 | 7.72 |
| CHEMBL366211 | — | — | 1 | 7.72 |
| CHEMBL372712 | — | — | 1 | 7.68 |
| CHEMBL190061 | — | — | 1 | 7.66 |
| CHEMBL189099 | — | — | 1 | 7.57 |
| CHEMBL191511 | — | — | 1 | 7.52 |
| CHEMBL189543 | — | — | 1 | 7.51 |
| CHEMBL192749 | — | — | 1 | 7.43 |
| CHEMBL189934 | — | — | 1 | 7.31 |
| CHEMBL363589 | — | — | 1 | 7.29 |
| CHEMBL189308 | — | — | 1 | 7.29 |
| CHEMBL189978 | — | — | 1 | 7.20 |
| CHEMBL191138 | — | — | 1 | 7.13 |
| CHEMBL189215 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365847 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL190281 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL370295 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL190627 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL189937 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL193167 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL190096 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL193177 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL373300 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL192827 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL189011 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL193184 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL192060 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL192308 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL371198 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL415773 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL366211 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL372712 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL190061 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL189099 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL191511 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL189543 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL192749 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL189934 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL363589 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL189308 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL189978 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL191138 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL189215 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL364029 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL189848 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL189579 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL190804 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL140272 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL190302 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL189317 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL366018 | — | IC50 | = | 595.0 | nM | 6.22 |
| CHEMBL365339 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL189745 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL189732 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL435302 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL189490 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL365529 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL427535 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL359761 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL425546 | — | IC50 | > | 5000.0 | nM | - |