Assay Detail
Binding
CHEMBL827900
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Inhibitory concentration against human cathepsin K
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A structural screening approach to ketoamide-based inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.47 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194068 | — | — | 1 | 8.60 |
| CHEMBL196896 | — | — | 1 | 8.52 |
| CHEMBL193582 | — | — | 1 | 8.24 |
| CHEMBL197509 | — | — | 1 | 8.14 |
| CHEMBL196298 | — | — | 1 | 7.58 |
| CHEMBL195963 | — | — | 1 | 7.50 |
| CHEMBL196240 | — | — | 1 | 7.00 |
| CHEMBL195301 | — | — | 1 | 6.72 |
| CHEMBL371749 | — | — | 1 | 6.46 |
| CHEMBL162812 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194068 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL196896 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL193582 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL197509 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL196298 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL195963 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL196240 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL195301 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL371749 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL162812 | — | IC50 | = | 1200.0 | nM | 5.92 |