Assay Detail
Binding
CHEMBL827906
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Inhibitory concentration against human cathepsin L
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Rational design of potent and selective NH-linked aryl/heteroaryl cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.30 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185431 | — | — | 1 | 6.97 |
| CHEMBL184859 | — | — | 1 | 6.94 |
| CHEMBL182956 | — | — | 1 | 6.45 |
| CHEMBL365007 | — | — | 1 | 6.34 |
| CHEMBL183306 | — | — | 1 | 5.68 |
| CHEMBL184514 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185431 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL184859 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL182956 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL365007 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL183306 | — | IC50 | = | 2101.0 | nM | 5.68 |
| CHEMBL184514 | — | IC50 | = | 3725.0 | nM | 5.43 |