Assay Detail
Binding
CHEMBL827914
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Inhibitory concentration against Matrix metalloprotease-1 (MMP-1)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.23 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370312 | — | — | 1 | 7.00 |
| CHEMBL190506 | — | — | 1 | 6.77 |
| CHEMBL191359 | — | — | 1 | 6.70 |
| CHEMBL190415 | — | — | 1 | 6.59 |
| CHEMBL189975 | — | — | 1 | 6.54 |
| CHEMBL179552 | — | — | 1 | 6.37 |
| CHEMBL372878 | — | — | 1 | 6.23 |
| CHEMBL189216 | — | — | 1 | 6.17 |
| CHEMBL190563 | — | — | 1 | 6.16 |
| CHEMBL372261 | — | — | 1 | 6.15 |
| CHEMBL192773 | — | — | 1 | 6.11 |
| CHEMBL189052 | — | — | 1 | 6.10 |
| CHEMBL190686 | — | — | 1 | 5.96 |
| CHEMBL189156 | — | — | 1 | 5.82 |
| CHEMBL190441 | — | — | 1 | 5.64 |
| CHEMBL191030 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370312 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL190506 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL191359 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL190415 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL189975 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL179552 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL372878 | — | IC50 | = | 592.0 | nM | 6.23 |
| CHEMBL189216 | — | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL190563 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL372261 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL192773 | — | IC50 | = | 773.0 | nM | 6.11 |
| CHEMBL189052 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL190686 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL189156 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL190441 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL191030 | — | IC50 | = | 5100.0 | nM | 5.29 |