Assay Detail
Binding
CHEMBL827972
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Inhibition of CHO-K1 cells expressing glucocorticoid receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
11beta-alkyl-Delta9-19-nortestosterone derivatives: high-affinity ligands and potent partial agonists of the androgen receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.65 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361245 | — | — | 1 | 9.05 |
| CHEMBL184313 | — | — | 1 | 6.90 |
| CHEMBL2311179 | — | — | 1 | 6.88 |
| CHEMBL189306 | — | — | 1 | 6.06 |
| CHEMBL186467 | — | — | 1 | 6.01 |
| CHEMBL184228 | — | — | 1 | 5.89 |
| CHEMBL186254 | — | — | 1 | 5.74 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361245 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL184313 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2311179 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL189306 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL186467 | — | IC50 | = | 979.0 | nM | 6.01 |
| CHEMBL184228 | — | IC50 | = | 1294.0 | nM | 5.89 |
| CHEMBL186254 | — | IC50 | = | 1812.0 | nM | 5.74 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.008 | nM | - |