Assay Detail
Binding
CHEMBL827985
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Inhibitory concentration against human ECE-1 by RIA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.27 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191879 | — | — | 1 | 8.16 |
| CHEMBL194651 | — | — | 1 | 7.98 |
| CHEMBL367315 | — | — | 1 | 7.92 |
| CHEMBL192441 | — | — | 1 | 7.80 |
| CHEMBL193490 | — | — | 1 | 7.30 |
| CHEMBL425383 | — | — | 1 | 7.21 |
| CHEMBL177000 | — | — | 1 | 7.09 |
| CHEMBL415967 | CGS-314447 | — | 1 | 4.70 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191879 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL194651 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL367315 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL192441 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL193490 | — | IC50 | = | 49.7 | nM | 7.30 |
| CHEMBL425383 | — | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL177000 | — | IC50 | = | 80.8 | nM | 7.09 |
| CHEMBL415967 | CGS-314447 | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 800.0 | nM | - |