Assay Detail
Binding
CHEMBL827987
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Inhibition of rat intestinal maltase using disaccharide
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.39 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187158 | — | — | 1 | 5.89 |
| CHEMBL186068 | — | — | 1 | 5.82 |
| CHEMBL186291 | — | — | 1 | 5.72 |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | 5.68 |
| CHEMBL364554 | — | — | 1 | 5.46 |
| CHEMBL186150 | — | — | 1 | 5.43 |
| CHEMBL184028 | — | — | 1 | 5.40 |
| CHEMBL362754 | — | — | 1 | 5.16 |
| CHEMBL3351101 | — | — | 1 | 4.92 |
| CHEMBL187208 | — | — | 1 | 4.37 |
| CHEMBL3349976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187158 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL186068 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL186291 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1029 | MIGLUSTAT | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL364554 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL186150 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL184028 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL362754 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3351101 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL187208 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3349976 | — | IC50 | = | 210000.0 | nM | - |