Assay Detail
Binding
CHEMBL828071
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Ki value against human carbonic anhydrase VII
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.75 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 9.35 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 9.11 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 9.06 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.68 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.55 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.46 |
| CHEMBL168552 | — | — | 1 | 8.40 |
| CHEMBL6753 | — | — | 1 | 8.37 |
| CHEMBL265674 | — | — | 1 | 8.28 |
| CHEMBL360356 | — | — | 1 | 8.27 |
| CHEMBL266026 | — | — | 1 | 8.25 |
| CHEMBL7146 | — | — | 1 | 8.19 |
| CHEMBL6633 | — | — | 1 | 8.17 |
| CHEMBL427312 | — | — | 1 | 8.15 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.58 |
| CHEMBL6705 | — | — | 1 | 7.35 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 7.28 |
| CHEMBL6919 | — | — | 1 | 7.22 |
| CHEMBL6724 | — | — | 1 | 7.21 |
| CHEMBL6784 | — | — | 1 | 7.18 |
| CHEMBL176495 | — | — | 1 | 7.17 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 7.16 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 7.12 |
| CHEMBL6853 | — | — | 1 | 7.12 |
| CHEMBL7087 | — | — | 1 | 7.10 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 7.06 |
| CHEMBL7204 | — | — | 1 | 7.05 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.00 |
| CHEMBL7092 | — | — | 1 | 6.92 |
| CHEMBL268177 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL168552 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL6753 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL265674 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL360356 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL266026 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL7146 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL6633 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL427312 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 26.5 | nM | 7.58 |
| CHEMBL6705 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL414 | CARZENIDE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL6919 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL6724 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL6784 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL176495 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL419 | MAFENIDE | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL6853 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL7087 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL7204 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL7092 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL268177 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL266240 | — | Ki | = | 210.0 | nM | 6.68 |